Japan raises ethical questions, chimeras


Animal research intended to create human organs in animals for saving human lives.

“In the recently-approved experiment, Dr Nakauchi and his team plan to create an animal embryo that lacks a particular gene essential for the formation of an organ, eg a kidney and then to add human iPS cells into the animal embryo. As the animal grows, the human iPS cells create the kidney. Dr Nakauchi intends to start with developing hybrid mice, followed by hybrid rats, and then hybrid pigs. Their ultimate aim is to produce animals with organs made of human cells that may eventually be transplanted into a human.”